Is Psoriasis Genetic?

 By: Cyril Wee
Have you ever bothered to find an answer to the question is psoriasis genetic? You may say you did not bother because you are not affected by the skin disorder. However, the truth is that psoriasis can affect you at any stage of your life and therefore you definitely need to find answer to the query is psoriasis genetic. This is because once you know the exact reasons behind your psoriasis infection it will become easier to treat and deal with it. In fact you need to know all you can about psoriasis for the sake of your own health.

Now, coming back to the question is psoriasis genetic. The answer is an emphatic yes. The skin disease of psoriasis has a very large hereditary component and several genes are associated with its occurrence. Though the answer to the question is psoriasis genetic is in the affirmative there is no concrete information on how these genes work in tandem. Usually the immune system is involved- especially the T-cells and the major histocompatibility complex (MHC) in most cases. The value of genetic studies lay in the fact that it identifies molecular mechanism and provides a guideline for further studies and drug targets.

Why is psoriasis genetic? This skin disorder is considered to be genetic because genomewide analyses have found there are nine locations on various chromosomes and they are strongly associated with the occurrence of psoriasis. They are known as psoriasis susceptibility and have been marked from 1 to 9, for example PSORS 1 - PSORS 9. Within these nine locations are genes. And most of these genes lay on pathways that cause inflammation and certain mutation of these genes are found in psoriasis. This is basically why the answer to is psoriasis genetic is a yes. This is the primary genetic cause of psoriasis.

When you get answer to the question is psoriasis genetic you will need to understand something quite vividly. That is psoriasis is generally caused by PSORS 1 and it is responsible for almost 50% of heritability. It actually controls the genes that are responsible for the health of your immune system and for the encoding proteins that is found in people who are affected by psoriasis. Chromosome 6 in MHC contains PSORS 1 and it is responsible for controlling the functions of your immune system. About 3 genes in this PSORS 1 have a link with psoriasis vulgaris. This lead to a positive answer to the question is psoriasis genetic.

When you ask is psoriasis genetic then knowing just about PSORS 1 will not suffice. Genomewide scans have detected several other genes that manifest altered characteristics during psoriasis. Some are characterized by inflamed signal proteins. This in turn affects the well being of the immune system that plays a crucial part in psoriasis. Some of these genes are responsible for some other autoimmune diseases as well. Once you got your answer to the question, is psoriasis genetic you will need to find about its treatments. Knowing the cause and initiating the treatments in time controls the spread of psoriasis.
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